Serveur d'exploration sur la grippe en Espagne

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.

Identifieur interne : 000269 ( Main/Exploration ); précédent : 000268; suivant : 000270

Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.

Auteurs : J. Castilla [Espagne] ; I. Martínez-Baz ; V. Martínez-Artola ; G. Reina ; F. Pozo ; M. García Cenoz ; M. Guevara ; J. Morán ; F. Irisarri ; M. Arriazu ; E. Albéniz ; C. Ezpeleta ; A. Barricarte

Source :

RBID : pubmed:23399423

Descripteurs français

English descriptors

Abstract

This study evaluates the influenza vaccine effectiveness (VE) in preventing laboratory-confirmed cases in Navarre, Spain, in the 2011/12 season in which the peak was delayed until week 7 of 2012. We conducted a test-negative case–control study. Patients with influenza-like illness in hospitals and primary healthcare were swabbed for testing by reverse transcription-polymerase chain reaction. Influenza vaccination status and other covariates were obtained from healthcare databases. The vaccination status of confirmed cases and negative controls was compared after adjusting for potential confounders. VE was calculated as (1-odds ratio)x100. The 411 confirmed cases (93% influenza A(H3)) were compared with 346 controls. Most characterised viruses did not match the vaccine strains. The adjusted estimate of VE was 31% (95% confidence interval (CI): -21 to 60) for all patients, 44% (95% CI: -11 to 72) for those younger than 65 years and 19% (95% CI: -146 to 73) for those 65 or older. The VE was 61% (95% CI: 5 to 84) in the first 100 days after vaccination, 42% (95% CI: -39 to 75) between 100 and 119 days, and zero thereafter. This decline mainly affected people aged 65 or over. These results suggest a low preventive effect of the 2011/12 seasonal influenza vaccine, and a decline in VE with time since vaccination.

DOI: 10.2807/ese.18.05.20388-en
PubMed: 23399423


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.</title>
<author>
<name sortKey="Castilla, J" sort="Castilla, J" uniqKey="Castilla J" first="J" last="Castilla">J. Castilla</name>
<affiliation wicri:level="1">
<nlm:affiliation>Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona, Spain. jcastilc@navarra.es</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martinez Baz, I" sort="Martinez Baz, I" uniqKey="Martinez Baz I" first="I" last="Martínez-Baz">I. Martínez-Baz</name>
</author>
<author>
<name sortKey="Martinez Artola, V" sort="Martinez Artola, V" uniqKey="Martinez Artola V" first="V" last="Martínez-Artola">V. Martínez-Artola</name>
</author>
<author>
<name sortKey="Reina, G" sort="Reina, G" uniqKey="Reina G" first="G" last="Reina">G. Reina</name>
</author>
<author>
<name sortKey="Pozo, F" sort="Pozo, F" uniqKey="Pozo F" first="F" last="Pozo">F. Pozo</name>
</author>
<author>
<name sortKey="Garcia Cenoz, M" sort="Garcia Cenoz, M" uniqKey="Garcia Cenoz M" first="M" last="García Cenoz">M. García Cenoz</name>
</author>
<author>
<name sortKey="Guevara, M" sort="Guevara, M" uniqKey="Guevara M" first="M" last="Guevara">M. Guevara</name>
</author>
<author>
<name sortKey="Moran, J" sort="Moran, J" uniqKey="Moran J" first="J" last="Morán">J. Morán</name>
</author>
<author>
<name sortKey="Irisarri, F" sort="Irisarri, F" uniqKey="Irisarri F" first="F" last="Irisarri">F. Irisarri</name>
</author>
<author>
<name sortKey="Arriazu, M" sort="Arriazu, M" uniqKey="Arriazu M" first="M" last="Arriazu">M. Arriazu</name>
</author>
<author>
<name sortKey="Albeniz, E" sort="Albeniz, E" uniqKey="Albeniz E" first="E" last="Albéniz">E. Albéniz</name>
</author>
<author>
<name sortKey="Ezpeleta, C" sort="Ezpeleta, C" uniqKey="Ezpeleta C" first="C" last="Ezpeleta">C. Ezpeleta</name>
</author>
<author>
<name sortKey="Barricarte, A" sort="Barricarte, A" uniqKey="Barricarte A" first="A" last="Barricarte">A. Barricarte</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23399423</idno>
<idno type="pmid">23399423</idno>
<idno type="doi">10.2807/ese.18.05.20388-en</idno>
<idno type="wicri:Area/Main/Corpus">00259</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00259</idno>
<idno type="wicri:Area/Main/Curation">000259</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000259</idno>
<idno type="wicri:Area/Main/Exploration">000259</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.</title>
<author>
<name sortKey="Castilla, J" sort="Castilla, J" uniqKey="Castilla J" first="J" last="Castilla">J. Castilla</name>
<affiliation wicri:level="1">
<nlm:affiliation>Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona, Spain. jcastilc@navarra.es</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martinez Baz, I" sort="Martinez Baz, I" uniqKey="Martinez Baz I" first="I" last="Martínez-Baz">I. Martínez-Baz</name>
</author>
<author>
<name sortKey="Martinez Artola, V" sort="Martinez Artola, V" uniqKey="Martinez Artola V" first="V" last="Martínez-Artola">V. Martínez-Artola</name>
</author>
<author>
<name sortKey="Reina, G" sort="Reina, G" uniqKey="Reina G" first="G" last="Reina">G. Reina</name>
</author>
<author>
<name sortKey="Pozo, F" sort="Pozo, F" uniqKey="Pozo F" first="F" last="Pozo">F. Pozo</name>
</author>
<author>
<name sortKey="Garcia Cenoz, M" sort="Garcia Cenoz, M" uniqKey="Garcia Cenoz M" first="M" last="García Cenoz">M. García Cenoz</name>
</author>
<author>
<name sortKey="Guevara, M" sort="Guevara, M" uniqKey="Guevara M" first="M" last="Guevara">M. Guevara</name>
</author>
<author>
<name sortKey="Moran, J" sort="Moran, J" uniqKey="Moran J" first="J" last="Morán">J. Morán</name>
</author>
<author>
<name sortKey="Irisarri, F" sort="Irisarri, F" uniqKey="Irisarri F" first="F" last="Irisarri">F. Irisarri</name>
</author>
<author>
<name sortKey="Arriazu, M" sort="Arriazu, M" uniqKey="Arriazu M" first="M" last="Arriazu">M. Arriazu</name>
</author>
<author>
<name sortKey="Albeniz, E" sort="Albeniz, E" uniqKey="Albeniz E" first="E" last="Albéniz">E. Albéniz</name>
</author>
<author>
<name sortKey="Ezpeleta, C" sort="Ezpeleta, C" uniqKey="Ezpeleta C" first="C" last="Ezpeleta">C. Ezpeleta</name>
</author>
<author>
<name sortKey="Barricarte, A" sort="Barricarte, A" uniqKey="Barricarte A" first="A" last="Barricarte">A. Barricarte</name>
</author>
</analytic>
<series>
<title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title>
<idno type="eISSN">1560-7917</idno>
<imprint>
<date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Confidence Intervals (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Infant, Newborn (MeSH)</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (isolation & purification)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (diagnosis)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Logistic Models (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Primary Health Care (MeSH)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Seasons (MeSH)</term>
<term>Sentinel Surveillance (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Time Factors (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Vaccination (statistics & numerical data)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Facteurs temps (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (diagnostic)</term>
<term>Grippe humaine (prévention et contrôle)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Intervalles de confiance (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Modèles logistiques (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>RT-PCR (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Saisons (MeSH)</term>
<term>Soins de santé primaires (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Surveillance sentinelle (MeSH)</term>
<term>Vaccination (statistiques et données numériques)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (isolement et purification)</term>
<term>Études cas-témoins (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr">
<term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Influenza A virus</term>
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en">
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr">
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr">
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Espagne</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Confidence Intervals</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Primary Health Care</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Seasons</term>
<term>Sentinel Surveillance</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs temps</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Intervalles de confiance</term>
<term>Jeune adulte</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>RT-PCR</term>
<term>Résultat thérapeutique</term>
<term>Saisons</term>
<term>Soins de santé primaires</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Surveillance sentinelle</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Espagne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">This study evaluates the influenza vaccine effectiveness (VE) in preventing laboratory-confirmed cases in Navarre, Spain, in the 2011/12 season in which the peak was delayed until week 7 of 2012. We conducted a test-negative case–control study. Patients with influenza-like illness in hospitals and primary healthcare were swabbed for testing by reverse transcription-polymerase chain reaction. Influenza vaccination status and other covariates were obtained from healthcare databases. The vaccination status of confirmed cases and negative controls was compared after adjusting for potential confounders. VE was calculated as (1-odds ratio)x100. The 411 confirmed cases (93% influenza A(H3)) were compared with 346 controls. Most characterised viruses did not match the vaccine strains. The adjusted estimate of VE was 31% (95% confidence interval (CI): -21 to 60) for all patients, 44% (95% CI: -11 to 72) for those younger than 65 years and 19% (95% CI: -146 to 73) for those 65 or older. The VE was 61% (95% CI: 5 to 84) in the first 100 days after vaccination, 42% (95% CI: -39 to 75) between 100 and 119 days, and zero thereafter. This decline mainly affected people aged 65 or over. These results suggest a low preventive effect of the 2011/12 seasonal influenza vaccine, and a decline in VE with time since vaccination.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">23399423</PMID>
<DateCompleted>
<Year>2013</Year>
<Month>04</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1560-7917</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>18</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2013</Year>
<Month>Jan</Month>
<Day>31</Day>
</PubDate>
</JournalIssue>
<Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title>
<ISOAbbreviation>Euro Surveill.</ISOAbbreviation>
</Journal>
<ArticleTitle>Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">20388</ELocationID>
<Abstract>
<AbstractText>This study evaluates the influenza vaccine effectiveness (VE) in preventing laboratory-confirmed cases in Navarre, Spain, in the 2011/12 season in which the peak was delayed until week 7 of 2012. We conducted a test-negative case–control study. Patients with influenza-like illness in hospitals and primary healthcare were swabbed for testing by reverse transcription-polymerase chain reaction. Influenza vaccination status and other covariates were obtained from healthcare databases. The vaccination status of confirmed cases and negative controls was compared after adjusting for potential confounders. VE was calculated as (1-odds ratio)x100. The 411 confirmed cases (93% influenza A(H3)) were compared with 346 controls. Most characterised viruses did not match the vaccine strains. The adjusted estimate of VE was 31% (95% confidence interval (CI): -21 to 60) for all patients, 44% (95% CI: -11 to 72) for those younger than 65 years and 19% (95% CI: -146 to 73) for those 65 or older. The VE was 61% (95% CI: 5 to 84) in the first 100 days after vaccination, 42% (95% CI: -39 to 75) between 100 and 119 days, and zero thereafter. This decline mainly affected people aged 65 or over. These results suggest a low preventive effect of the 2011/12 seasonal influenza vaccine, and a decline in VE with time since vaccination.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Castilla</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Instituto de Salud Publica de Navarra (Public Health Institute of Navarre), Pamplona, Spain. jcastilc@navarra.es</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Martínez-Baz</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Martínez-Artola</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Reina</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Pozo</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y">
<LastName>García Cenoz</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Guevara</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Morán</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Irisarri</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Arriazu</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Albéniz</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Ezpeleta</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Barricarte</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y">
<CollectiveName>Primary Health Care Sentinel Network</CollectiveName>
</Author>
<Author ValidYN="Y">
<CollectiveName>Network for Influenza Surveillance in Hospitals of Navarre</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D023362">Evaluation Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2013</Year>
<Month>01</Month>
<Day>31</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Sweden</Country>
<MedlineTA>Euro Surveill</MedlineTA>
<NlmUniqueID>100887452</NlmUniqueID>
<ISSNLinking>1025-496X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011320" MajorTopicYN="N">Primary Health Care</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018571" MajorTopicYN="N">Sentinel Surveillance</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<InvestigatorList>
<Investigator ValidYN="Y">
<LastName>Abad</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Aldaz</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Álvarez</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Arana</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Arceiz</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Arina</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Artajo</LastName>
<ForeName>M D</ForeName>
<Initials>MD</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Arza</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Azagra</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bartolome</LastName>
<ForeName>F C</ForeName>
<Initials>FC</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bernués</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Berraondo</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bolea</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Brugos</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Buil</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cano</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Castresana</LastName>
<ForeName>M V</ForeName>
<Initials>MV</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cenoz</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cia</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Compains</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cortés</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Churío</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Da Costa</LastName>
<ForeName>E M</ForeName>
<Initials>EM</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Díez Espino</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Doiz</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Escribano</LastName>
<ForeName>F J</ForeName>
<Initials>FJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Esparza</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Etayo</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fanlo</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fernández Alfaro</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Flamarique</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gamboa</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gembero</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>German</LastName>
<ForeName>A B</ForeName>
<Initials>AB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Giner</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gómara</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Goñi</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Guillorme</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Guiu</LastName>
<ForeName>J O</ForeName>
<Initials>JO</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gurbindo</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Guruchaga</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Heras</LastName>
<ForeName>J A</ForeName>
<Initials>JA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hijos</LastName>
<ForeName>M C</ForeName>
<Initials>MC</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Indurain</LastName>
<ForeName>M S</ForeName>
<Initials>MS</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Iñigo</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Juan Belloc</LastName>
<ForeName>S E</ForeName>
<Initials>SE</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Jurio</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lecea</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>León</LastName>
<ForeName>M P</ForeName>
<Initials>MP</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Longás</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Maquirriain</LastName>
<ForeName>M T</ForeName>
<Initials>MT</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Miner</LastName>
<ForeName>J J</ForeName>
<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Montoya</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Moreno</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Navarro</LastName>
<ForeName>U</ForeName>
<Initials>U</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Olmedo</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Orozco</LastName>
<ForeName>F J</ForeName>
<Initials>FJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Orte</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Palau</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pérez Afonso</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pérez Lecumberri</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pérez Pascual</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Prado Virto</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Prado Santamaria</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Puig Arrastia</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ridruejo</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ramos</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rípodas</LastName>
<ForeName>B E</ForeName>
<Initials>BE</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rodríguez</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Roncal</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ruiz Puertas</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sánchez Vázquez</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Senosiain</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sola</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sota</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Uhalte</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ursua</LastName>
<ForeName>M E</ForeName>
<Initials>ME</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Urtasun</LastName>
<ForeName>I A</ForeName>
<Initials>IA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Vigata</LastName>
<ForeName>M J</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Virto</LastName>
<ForeName>M T</ForeName>
<Initials>MT</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Vizcay</LastName>
<ForeName>J M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Artajo</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bernaola</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Chamorro</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fanlo</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gil</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gabari</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hueto</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Maraví</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pérez</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ruiz</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Núñez</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Navascués</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ortega</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Torres</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lameiro</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Petit</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="entrez">
<Year>2013</Year>
<Month>2</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2013</Year>
<Month>2</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2013</Year>
<Month>4</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">23399423</ArticleId>
<ArticleId IdType="doi">10.2807/ese.18.05.20388-en</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Espagne</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Albeniz, E" sort="Albeniz, E" uniqKey="Albeniz E" first="E" last="Albéniz">E. Albéniz</name>
<name sortKey="Arriazu, M" sort="Arriazu, M" uniqKey="Arriazu M" first="M" last="Arriazu">M. Arriazu</name>
<name sortKey="Barricarte, A" sort="Barricarte, A" uniqKey="Barricarte A" first="A" last="Barricarte">A. Barricarte</name>
<name sortKey="Ezpeleta, C" sort="Ezpeleta, C" uniqKey="Ezpeleta C" first="C" last="Ezpeleta">C. Ezpeleta</name>
<name sortKey="Garcia Cenoz, M" sort="Garcia Cenoz, M" uniqKey="Garcia Cenoz M" first="M" last="García Cenoz">M. García Cenoz</name>
<name sortKey="Guevara, M" sort="Guevara, M" uniqKey="Guevara M" first="M" last="Guevara">M. Guevara</name>
<name sortKey="Irisarri, F" sort="Irisarri, F" uniqKey="Irisarri F" first="F" last="Irisarri">F. Irisarri</name>
<name sortKey="Martinez Artola, V" sort="Martinez Artola, V" uniqKey="Martinez Artola V" first="V" last="Martínez-Artola">V. Martínez-Artola</name>
<name sortKey="Martinez Baz, I" sort="Martinez Baz, I" uniqKey="Martinez Baz I" first="I" last="Martínez-Baz">I. Martínez-Baz</name>
<name sortKey="Moran, J" sort="Moran, J" uniqKey="Moran J" first="J" last="Morán">J. Morán</name>
<name sortKey="Pozo, F" sort="Pozo, F" uniqKey="Pozo F" first="F" last="Pozo">F. Pozo</name>
<name sortKey="Reina, G" sort="Reina, G" uniqKey="Reina G" first="G" last="Reina">G. Reina</name>
</noCountry>
<country name="Espagne">
<noRegion>
<name sortKey="Castilla, J" sort="Castilla, J" uniqKey="Castilla J" first="J" last="Castilla">J. Castilla</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000269 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000269 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeEspagneV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:23399423
   |texte=   Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23399423" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeEspagneV1 

Wicri

This area was generated with Dilib version V0.6.37.
Data generation: Fri Sep 25 11:01:38 2020. Site generation: Sat Feb 13 17:38:04 2021